Serum homocysteine is weakly associated with von Willebrand factor and soluble vascular cell adhesion molecule 1, but not with C-reactive protein in type 2 diabetic and non-diabetic subjects ÿ The Hoorn Study
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چکیده
Background Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was ®rstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade in ̄ammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively. Secondly we investigated whether the presence of type 2 diabetes modi®es these associations. Materials and Methods Six hundred and ten subjects of a general population of middleaged and elderly subjects, 170 of whom had type 2 diabetes, participated in this crosssectional study. Linear regression analyses were used to study whether tHcy was associated with vWf, sVCAM-1 and CRP, and whether the presence of diabetes modi®ed these associations. Results After adjustment for confounders, tHcy was signi®cantly but weakly associated with vWf (b 0 ́15, P 0 ́05) and sVCAM-1 (b 0 ́082, P 0 ́04). tHcy was not signi®cantly associated with CRP (b 0 ́02, P 0 ́91). The presence of diabetes did not signi®cantly modify these associations. Conclusions This study provides evidence that tHcy is, at most, weakly associated with endothelial dysfunction as estimated from plasma vWf, and with leukocyte adhesion as estimated from plasma sVCAM-1. tHcy was not signi®cantly associated with chronic lowgrade in ̄ammation as estimated from plasma CRP. Our data thus suggest that the link between tHcy and atherothrombosis cannot be explained by associations of tHcy with vWf, sVCAM-1 or CRP.
منابع مشابه
Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.
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تاریخ انتشار 2000